There are now 3 airlines offering flights from Ambon to Saumlaki: Merpati (the last resort only!), Expressair and Trigana. Between them, they fly at least daily. Fares are high, though as compatition increases, they seem to be going down. Merpati also connects (at least in theory) Saumlaki with Kisar in SW Maluku.
Within the Tanimbars, Merpati is scheduled to have a weekly flight between Saumlaki and Larat, though this is usually very heavily-booked and frequently cancelled.
Two or three Pelni ships stop at Saumlaki a few times a month between Nusa Tenggara, Central Maluku, Tual and Papua.
There are also several Perintis cargo ships from Ambon, SE Maluku and the remoter islands of SW Maluku.
The most regular way to reach the Tanimbars by sea has long been the weekly Karomolin car ferry from Tual in the Keis (on Mondays), but as of 2010 that was no longer serving Saumlaki, just Larat in the northern Tanimbars.
Irregular local boats and the odd Perintis are the only way to reach villages on the north-western coast of Yamdena.